Sp 02 Sas @ Application in 2 * 2 Crossover Clinical Trial
نویسندگان
چکیده
Crossover clinical trial design attracts a lot of attention in today’s drug development environment because of its unique characteristics. This paper will start with an introduction of a 2 * 2 crossover clinical trial design, then a review of advantages and disadvantages of cross over studies compared with parallel studies. Different types of SAS procedure, such as PROC TTEST, PROC GLM and PROC MIXED will be used as demonstration on how to analyze the data if response variable is continuous. McNemar test, Mainland-Gart test, Prescott test will also be reviewed if the outcome measurement is a binary variable. The paper closes with an example using simulated data.
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